Draxxin 100mg/mL (Tulathromycin) 100mL Injection

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This item is a prescription medication. A prescription is required from your veterinarian before we can supply this product. Please ensure that you have read the "How to Order" page before ordering this item.

All of Pet Care Pharmacy’s prescription medications are APVMA or TGA approved and are also identical to those supplied by your veterinarian.



Draxxin® is a ready-to-use antibiotic injection that provides a complete course of therapy for bovine and swine respiratory disease in a single dose.


Tulathromycin, the active ingredient of Draxxin® is a triamilide antimicrobial. It is a new class of macrolide, with unique structure and features, that is derived from azalide macrolides (unlike tilmicosin, which is a semi-synthetic derivative of tylosin). Tulathromycin shares the fundamental macrolide mode of action and destroys bacteria by binding to the 50S subunit of bacterial ribosomes (site of protein synthesis). It also has a unique ability to punch through the cell wall of gram negative bacteria. Therefore, unlike other macrolide anitiboioics, tulathromycin has both bacteriostatic and bactericidal properties.

Draxxin® exhibits exceptional pharmacokinetics in cattle and pigs:

Rapid release and absorption from the injection site

  • Tulathromycin attans therapeutic blood levels almost as quickly from S/C and I/M injection sites an intravenous injection.

Extensive distribution

  • Tulathromycin distributes widely within tissues of the body.

Slow elimination profile

  • Tulathromycin due to its unique chemical structure, is slowly eliminated from lung tissue, improving the duration of effect from a single dose.

High, prolonged lung tissue concentrations

  • Tulathromycin accumulates in lung tissue and persists at therapeutic levels for between 9 and 15 days, depending on the target organism.

 Other physico-chemical features and properties of tulathromycin include :

  • Substantial lipophilic characteristics giving the drug the ability to punch through Gram negative cell walls.
  • Increased metabolic stability. Tulathromycin is not metabolised significantly within the body of treated animals and is excreted largely unchanged through urine and bile.
  • Chemical stability and good aqueous solubility. This means that the drug is widely distributed throughout the body.
  • Low affinity for efflux pumps. (This has been demonstrated in defined mutant strains of E. coli, suggesting the drug may not be easily removed from bacterial cells). This is a mechanism used by Gram negative cells to remove antibiotics from the cell.

Tulathromycin also accumulates in immune cells. This phenomenon can enhance drug concentration where immune cells congregate in infected tissues, which occurs in damaged lung tissue in cases of bovine and swine respiratory disease.

For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica and Pasteurella multocida sensitive to tulathromycin

For the treatment of swine respiratory disease (SRD) associated with Pasteurella multocida and Mycoplasma hyopneumoniae sensitive to tulathromycin.


Single subcutaneous (SC) injection in the neck of cattle or intramuscular (IM) in the neck of pigs.

  • 2.5mg tulathromycin/kg body weight (1mL/40kg body weight).
  • For cattle over 400kg , divide the dose so that no more than 10mL are injected at one site.
  • Withholding Periods:

Cattle: 35 days, ESI 35 days
Swine: 14 days, ESI 26 days

DO NOT USE in cows which are producing or may in the future produce milk or milk products for human consumption.

  • Retreatment Intervals:
    Cattle: 12 weeks
    Swine: 8 weeks

Delivers longer activity against major BRD pathogens

  • Draxxin® Injectable Solution concentrates in lung tissues.  Its slow elimination leads to an 8 day half life in lung tissue.
  • Slow elimination means Draxxin® Injectable Solution provides 9 to 15 days of activity above MICs for key respiratory bacterial pathogens M. haemolytica (MIC90 = 2μg/mL) and P. multocida (MIC90 = 1μg/mL).

More effective than Micotil and Nuflor

  • Fewer repulls – first treatment success was higher for cattle treated with Draxxin® Injectable Solution than for cattle which received Micotil or Nuflor
  • Fewer chronics and mortalities – BRD removals were lower in cattle treated with Draxxin® Injectable Solution than for cattle which received Micotil or Nuflor


  • Draxxin® Injectable Solution has an excellent safety profile – administration of up to 10 times the recommended dose was well-tolerated, producing no serious adverse effects.
  • Good for cattle, good for workers.


  • Full course treatment in a single SC dose.
  • Highly syringeable, ready to use, clear aqueous solution.
  • Packaged in 50mL and 100mL glass vials.


  • 1mL/40kg, low dose volume
  • One vial of Draxxin® Injectable Solution treats more animals than either Micotil or Nuflor.



  • Injectable, ready-to-use, sterile aqueous solution (propylene glycol/water) containing 100mg tulathromycin/mL
  • Packaged in multi-dose glass vials of 50mL and 100mL
  • 36-month shelf life period when stored at room temperature (< 30°C)
  • Photostable (clear vials)
  • Low viscosity, even at -10°C
  • Excellent syringeability


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Additional Information

For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica and Pasteurella multocida sensitive to tulathromycin. For the treatment of swine respiratory disease (SRD) associated with Pasteurella multocida and Mycoplas
DO NOT USE in cows which are producing or may in the future produce milk or milk products for human consumption.
Trade Name:
Active Ingredient:
Tulathromycin 100mg/mL
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